BRCA1 and BRCA2
Could blocking these proteins stop breast cancer?

Could blocking these proteins stop breast cancer? Researchers have discovered that blocking certain proteins that respond to progesterone prevent breast cancer in those who carry high-risk genes. Carrying BRCA1 and BRCA2 tumor suppressor gene mutations raises the risk of developing cancer.

This study was reported on in Genetic Engineering  & Biotechnology  News. Their article was published 20, June 2018. You can read Breast Cancer Epigenetics Study Reveals Potential Drug Targets.

“Epigenetic proteins cause “mammary gland stem cell” numbers to increase when exposed to progesterone. During menstruation and pregnancy, a surge in progesterone levels spurs an increase in basal and luminal stem cells, resulting in expansion of the mammary glands. Prof. Khokha says that this shows that the action of certain epigenetic molecules on mammary gland stem cells “is conserved between mice and humans,” and that there is potential for developing “epigenetic therapies” as chemoprevention for human breast cancer.” Catharine Paddock PhD

Researcher and author of this study Rama Khokha, a senior scientist at Princess Margaret Cancer Centre and professor of biophysics at the University of Toronto, said “Currently there are no standard of care preventative interventions for women at high risk of breast cancer.”
“Chemoprevention” Potential

Prof. Khokha says this shows that the action of certain epigenetic molecules on mammary gland stem cells “is conserved between mice and humans.” There is potential for developing “epigenetic therapies” as chemoprevention for human breast cancer.

Learn more about this latest discovery here.

Medical News Today reported on this study here.

Link to other breast cancer posts on CancerSmarter.com here and here.



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