Coffee Intake Decreases Risk of Postmenopausal Breast Cancer

This study suggests that coffee intake decreases risk of postmenopausal breast cancer. Coffee has many compounds that have been reported to reduce this risk, including caffeic acid, caffeine, polyphenols, volatile aroma and heterocyclic molecules. Coffee is also a source of acrylamide, a suspected carcinogen.

A new meta-analysis of previous studies was designed to investigate the associations between coffee consumption and risk of breast cancer. The findings were reported in the journal MDPI — Nutrients. The authors combined data from 21 prospective studies. Overall and subgroup analyses were performed, taking into account menopausal and hormone receptor (ER/PR) status, smoking and body mass index (BMI).

Confounding Factors

Confounding factors were considered and are stated as possibly limiting the results of this study. Factors such as alcohol consumption and education suggest that better designed cohort studies properly adjusted for potential confounding factors may enhance the overall quality of comprehensive quantitative synthesis and lead to significant results toward lower risk of breast cancer associated with higher consumption of coffee.

This study revealed significant results for post-menopausal women. Several mechanisms have been proposed to have influence specifically in the occurrence of female cancers for example, caffeine and coffee intake have been inversely associated with free estradiol levels in premenopausal women, either directly or indirectly.

You can read the study here.